Indicate whether the following events occur during somatic hypermutation (SHM), class switching (CS), neither (N), or bo
Posted: Tue Jul 05, 2022 8:50 am
Indicate whether the following events occur during somatic hypermutation (SHM), class switching (CS), neither (N), or both (B).
_______ Activation induced cytidine deaminase converts cytidines to uridines in double-stranded (base paired) regions of DNA
_______ Activation induced cytidine deaminase converts cytidines to uridines in single-stranded regions of DNA
_______ Uracil-N-glycosylase removes uridine bases and Apyrimidinic Endonuclease I cleaves the phosphodiester bond at the abasic site.
_______ The DSBR/NHEJ machinery is recruited
_______ AID is targeted to CDR1-3
_______ AID is targeted to s regions
_______ Activation induced cytidine deaminase converts cytidines to uridines in double-stranded (base paired) regions of DNA
_______ Activation induced cytidine deaminase converts cytidines to uridines in single-stranded regions of DNA
_______ Uracil-N-glycosylase removes uridine bases and Apyrimidinic Endonuclease I cleaves the phosphodiester bond at the abasic site.
_______ The DSBR/NHEJ machinery is recruited
_______ AID is targeted to CDR1-3
_______ AID is targeted to s regions