Biochemistry
Posted: Tue Jul 05, 2022 7:41 am
Biochemistry
QUESTION 7 We extensively discussed the findings of the paper published in "Molecular Cell 21, 711-717, 2006" in our lectures. Briefly, the paper reports that the tyrosine itself and that kinase FGFR1 autophosphorylates autophosphorylation is mediated by a sequential and precisely ordered reaction. A diagram describing the autophosphorylation sites of FGFR1 and a native gel of different FGFR1 autophosphorylation states are shown. 398 Tryp1 458 480 B) 1P 576 Tryp2 FGFR1K Tryp3 Tryp4 596 761 765 7.1 Which amino acid was mapped to: A) OP 7.2 If Y463 were mutated to a threonine CO₂H A) how many autophosphorylation sites would there be? B) which amino acids would be autophosphorylated? OP 1P 2P 3P Pesc 4P 5P (1) (1) (2) (2)
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