2 A 56-year-old man was initiated on allopurinol 200 mg once daily and naproxen 750 mg once, followed by 250 mg three ti
Posted: Mon Apr 04, 2022 6:37 am
2 A 56-year-old man was initiated on allopurinol 200 mg once daily and naproxen 750 mg once, followed by 250 mg three times daily, about 2 months ago after receiving a diagnosis of acute gout. On diag nosis, no tophi were present, uric acid was 10.9 mg/dL, and GFR was 78 mL/minute/1.73 m2 At his follow-up appointment, 1 month ago, his allopuri nol dose was increased to 300 mg once daily and naproxen was discontinued because his symptoms had resolved; his uric acid concentration was 8.7 mg/dL and GFR was 84 mL minute/1.73 m2. He presents today with complaints of a new rash, uric acid concentration 7.4 mg/dL, and GFR 72 mL/minute/1.73 m2. Which is the best choice for man aging his gout today? A. Increasing allopurinol to 400 mg once daily. B. Resuming naproxen 250 mg three times daily. C. Changing to febuxostat 40 mg once daily. D. Changing to pegloticase 8 mg intravenously every 2 weeks. Sol:-