Answer Happy

Epinephrine binds to a G-protein linked receptor present on the liver cells and activates the G-protein signaling pathway within the cell. This signally cascade finally activates the enzyme glycogen Phosphorylases. The activated glycogen Phosphorylases then produces Glucose-1 Phosphate from the breakdown of glycogen. This glucose is then released into bloodstream. Suppose the cell receives a drug that inhibits the enzyme activity of Phosphodiesterase, an enzyme which inactivates CAMP by converting it to AMP. You know that this enzyme is activated when the cell does not want any more epinephrine activity and thus epinephrine doesnot bind to the receptor any longer and which in turn inactivates G-protein and adenylate cyclase. So which of the following will hold true (select all that apply) in the presence of this drug after the cell no longer needs epinephrine activity: Multiple answers: Multiple answers are accepted for this question Select one or more answers and submit. For keyboard navigation... SHOW MORE b C d epinephrine will no longer bind to the receptor as this drug does not have a receptor effect on the binding of epinephrine to the G-protein will get inactive by hydrolyzing the GTP to GDP since this drug does not effect this process Adenylate cyclase will be inactivated since G-protein is inactivated and this drug does not effect adenylate cyclase The concentration of CAMP will remain high in the cell even in the absence of epinephrine signal since the drug inhibits phosphodiesterase which destroys CAMP In the presence of high CAMP-the down stream signaling will continue and the cell will continue to release glucose-1- phosphate from glycogen The blood sugar level will continue to be high since glucose is released from the cells.