Answer Happy

5. Write each codon per line and HIGHLIGHT in yellow where the deleted base occurred and affected amino acids. Original DNA TAC GGA CGA TCT CAG GAG CCT ATA ATC Deletion DNA Mutated mRNA AGU CCU GCU AGA GUC CUC GGA UUA UAG Mutated Amino Acids Met Pro Ala Arg Ser Pro Arg Tle Leu Original Amino Acid Met Pro Ala Arg Val Leu Gly Tyr STOP BASE SUBSTITUTION MUTATION (change ONE base) 6. Write each codon per line and HIGHLIGHT in yellow the substituted base and resulting amino acid. Original DNA TAC БАТ GCA GAT CTG GCC CAG TTC ATC Base Substitution DNA Mutated mRNA Mutated Amino Acids Original Amino Acid Met Val Arg Leu Asp Arg Val Lys STOP

b. IF your #6 resulted in a different amino acid - you must find a base substitution that will result in the same amino acid. Write each codon per line and HIGHLIGHT in yellow the substituted base and resulting amino acid. Original DNA TAC CAT GCA GAT CTG GCC CAG TTC ATC Base Substitution DNA Mutated mRNA Mutated Amino Acids Original Amino Acid Met Val Arg Leu Asp Arg Val Lys STOP

Directions: 1. Use the sequence to create RNA and the sequence of amino acids. (Use the codon chart at the bottom of this assignment) DNA of HbA - hemoglobin in normal adults DNA 3'to 5' CAC GTG GAC TGA GGA CTT CTC RNA Amino Acid 2. Each amino acid in the chain joins together and then folds into a three-dimensional shape - a PROTEIN. In most people, that protein is fully functional and results in blood cells that have a round shape and can bind with oxygen efficiently. What would happen if one small change occurs? 3. Complete the chart that shows the DNA of an individual who has sickle cell anemia. DNA of Hbs - hemoglobin found in individuals with sickle cell anemia - DNA CAC GTG GAC TGA GGA CAT СТС RNA Amino Acid