You have an animal model of Amyotrophic Lateral Sclerosis (ALS) in which there is a mutation in one of the proteins that
Posted: Thu Jun 30, 2022 6:34 pm
You have an animal model of Amyotrophic Lateral Sclerosis (ALS)in which there is a mutation in one of the proteins that make updynein. Which of the following is CORRECT?
a.You would predict that retrograde transport is abnormal inaxons but both anterograde and retrograde transport might beaffected in dendrites since dynein is a plus-end directedmotor.
b.You would predict that retrograde transport is abnormal inaxons but both anterograde and retrograde transport might beaffected in dendrites since dynein is a minus-end directedmotor.
You would predict that anterograde transport is abnormal inaxons but both anterograde and retrograde transport might beaffected in dendrites since dynein is a plus-end directedmotor.
d.You would predict that anterograde transport is abnormal inaxons but both anterograde and retrograde transport might beaffected in dendrites since dynein is a minus-end directedmotor
You would predict that retrograde transport is abnormal indendrites but both anterograde and retrograde transport might beaffected in axons since dynein is a plus-end directed motor
2. In the lab, there is a receptor that is found mostly indendrites, but during development it is also found in presynapticterminals. You would like to determine the effects of thepresynaptic receptors on development. In order to isolate theeffects of presynaptic receptors, you do not want to interfere withthe postsynaptic receptors. You decide that your first approachwill be to prevent deliver of the receptors to presynapticterminals by mutating one of the motor proteins that transportsthis protein. Which motor would you mutate to accomplish yourgoal?
a.KIF5, a kinesin
b.dynein
c.Myosin Va
d.Myosin VI
e.none of the above
a.You would predict that retrograde transport is abnormal inaxons but both anterograde and retrograde transport might beaffected in dendrites since dynein is a plus-end directedmotor.
b.You would predict that retrograde transport is abnormal inaxons but both anterograde and retrograde transport might beaffected in dendrites since dynein is a minus-end directedmotor.
You would predict that anterograde transport is abnormal inaxons but both anterograde and retrograde transport might beaffected in dendrites since dynein is a plus-end directedmotor.
d.You would predict that anterograde transport is abnormal inaxons but both anterograde and retrograde transport might beaffected in dendrites since dynein is a minus-end directedmotor
You would predict that retrograde transport is abnormal indendrites but both anterograde and retrograde transport might beaffected in axons since dynein is a plus-end directed motor
2. In the lab, there is a receptor that is found mostly indendrites, but during development it is also found in presynapticterminals. You would like to determine the effects of thepresynaptic receptors on development. In order to isolate theeffects of presynaptic receptors, you do not want to interfere withthe postsynaptic receptors. You decide that your first approachwill be to prevent deliver of the receptors to presynapticterminals by mutating one of the motor proteins that transportsthis protein. Which motor would you mutate to accomplish yourgoal?
a.KIF5, a kinesin
b.dynein
c.Myosin Va
d.Myosin VI
e.none of the above