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Question 26 The following pharmacokinetic data for N-acetylprocainamide (NAPA) were obtained in a Phase 1 study in volun
Posted: Thu Jun 30, 2022 6:18 pm
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- Question 26 The Following Pharmacokinetic Data For N Acetylprocainamide Napa Were Obtained In A Phase 1 Study In Volun 1 (40.29 KiB) Viewed 66 times
Question 26 The following pharmacokinetic data for N-acetylprocainamide (NAPA) were obtained in a Phase 1 study in volunteers with normal kidney function: • Elimination half-life: 6.2 h. • Elimination clearance: 233 mL/min. • % Renal excretion: 75.8% Use these results to predict the elimination half-life of NAPA in functionally anephric patients, assuming that nonrenal clearance is unchanged in these individuals. 25.6 h 12.4 h 42.7 h 1 pts 35.6 h 8.2 h