Answer Happy

(D) Among the following, identify the structure that meets the specified criterion. OH +₂ (C) (A) Chair conformation (-)-menthol: Chair conformation of enantiomer of (-)-menthol: HO Chair conformation of a diastereomer of (-)-menthol: (B) Chair conformation of a constitutional isomer of (-)-menthol: OH NH₂ Leukotriene D4 Problem 5: Leukotriene D4 is an endogenous inflammatory mediator that triggers contractions in smooth muscles lining the bronchioles - a major cause of asthma and allergic rhinitis. Thus, leukotriene receptor antagonists such as montelukast (Singulair™M) are commonly prescribed to treat asthama. Answer the following questions based on the structure of leukotriene D4 and montelukast below. OH x HO (D) OH Montelukast (Singulair™M) A) Total number of asymmetric centers in Leukotriene D4 (B) Total number of stereogenic centers in Leukotriene D4 (C) Total number of (Z)-alkenes in Leukotriene D4 (D) Assign (R) or (S) configuration to all asymmetric centers in Leukotriene D4 above. (E) Assign R/S configuration to the asymmetric center and E/Z configuration to the alkene in Montelukast