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What is the concentration of a theophylline 12 hr. after administration of a loading dose of 20 mg (oral tablet) and sim

Posted: Tue Mar 15, 2022 3:08 pm
by answerhappygod
What is the concentration of a theophylline 12 hr. after
administration of a loading dose of 20 mg (oral tablet) and
simultaneous infusion at 5 mg/hr. to a 75 kg male patient.
The
available product in the clinic is Aminophylline (an
Ethylenediamine
salt of theophylline with a salt form of 0.85 and bioavailability
of 100
%). Theophylline has an elimination half-life of 8 hours and a
volume
of distribution (Vd) of 0.5 L/kg