Abstract There has been enormous debate regarding the possibility of a link between childhood vaccinations and the subse
Posted: Tue Mar 15, 2022 2:53 pm
Abstract
There has been enormous debate regarding the possibility of a
link between childhood vaccinations and the subsequent development
of autism. This has in recent times become a major public health
issue with vaccine preventable diseases increasing in the community
due to the fear of a 'link' between vaccinations and autism. We
performed a meta-analysis to summarise available evidence from
case-control and cohort studies on this topic (MEDLINE, PubMed,
EMBASE, Google Scholar up to April, 2014). Eligible studies
assessed the relationship between vaccine administration and the
subsequent development of autism or autism spectrum disorders
(ASD). Two reviewers extracted data on study characteristics,
methods, and outcomes. Disagreement was resolved by consensus with
another author. Five cohort studies involving 1,256,407 children,
and five case-control studies involving 9,920 children were
included in this analysis. The cohort data revealed no relationship
between vaccination and autism (OR: 0.99; 95% CI: 0.92 to 1.06) or
ASD (OR: 0.91; 95% CI: 0.68 to 1.20), nor was there a relationship
between autism and MMR (OR: 0.84; 95% CI: 0.70 to 1.01), or
thimerosal (OR: 1.00; 95% CI: 0.77 to 1.31), or mercury (Hg) (OR:
1.00; 95% CI: 0.93 to 1.07). Similarly the case-control data found
no evidence for increased risk of developing autism or ASD
following MMR, Hg, or thimerosal exposure when grouped by condition
(OR: 0.90, 95% CI: 0.83 to 0.98; p=0.02) or grouped by exposure
type (OR: 0.85, 95% CI: 0.76 to 0.95; p=0.01). Findings of this
meta-analysis suggest that vaccinations are not associated with the
development of autism or autism spectrum disorder. Furthermore, the
components of the vaccines (thimerosal or mercury) or multiple
vaccines (MMR) are not associated with the development of autism or
autism spectrum disorder.
Meta Analysis urnal Club al Evidence + ce Updates Systematic Reviews Critically Appraised Sources ed/Filtered Randomized Controlled Trials Cohort Studies Unfiltered Case Control Studies Case Reports/ Case Series Background Information & Expert Opinion
There has been enormous debate regarding the possibility of a
link between childhood vaccinations and the subsequent development
of autism. This has in recent times become a major public health
issue with vaccine preventable diseases increasing in the community
due to the fear of a 'link' between vaccinations and autism. We
performed a meta-analysis to summarise available evidence from
case-control and cohort studies on this topic (MEDLINE, PubMed,
EMBASE, Google Scholar up to April, 2014). Eligible studies
assessed the relationship between vaccine administration and the
subsequent development of autism or autism spectrum disorders
(ASD). Two reviewers extracted data on study characteristics,
methods, and outcomes. Disagreement was resolved by consensus with
another author. Five cohort studies involving 1,256,407 children,
and five case-control studies involving 9,920 children were
included in this analysis. The cohort data revealed no relationship
between vaccination and autism (OR: 0.99; 95% CI: 0.92 to 1.06) or
ASD (OR: 0.91; 95% CI: 0.68 to 1.20), nor was there a relationship
between autism and MMR (OR: 0.84; 95% CI: 0.70 to 1.01), or
thimerosal (OR: 1.00; 95% CI: 0.77 to 1.31), or mercury (Hg) (OR:
1.00; 95% CI: 0.93 to 1.07). Similarly the case-control data found
no evidence for increased risk of developing autism or ASD
following MMR, Hg, or thimerosal exposure when grouped by condition
(OR: 0.90, 95% CI: 0.83 to 0.98; p=0.02) or grouped by exposure
type (OR: 0.85, 95% CI: 0.76 to 0.95; p=0.01). Findings of this
meta-analysis suggest that vaccinations are not associated with the
development of autism or autism spectrum disorder. Furthermore, the
components of the vaccines (thimerosal or mercury) or multiple
vaccines (MMR) are not associated with the development of autism or
autism spectrum disorder.
- Abstract There Has Been Enormous Debate Regarding The Possibility Of A Link Between Childhood Vaccinations And The Subse 1 (356.05 KiB) Viewed 45 times