(a) Provide a definition of the Hill coefficient. Answer this question using both a mathematical equation as well as a w
Posted: Sat Feb 26, 2022 11:57 am
(a) Provide a definition of the Hill coefficient. Answer this
question using both a mathematical equation as well as a written
explanation of what this parameter describes.
(b) Consider a dimeric protein complex, wherein each subunit of
the dimer can bind to a single substrate molecule. The KD1 for
first binding site is 1 μM and the KD2 for the second binding site
is 10 nM. What is the Hill coefficient for this protein system?
Does it display positive or negative cooperativity? Explain your
answer.
question using both a mathematical equation as well as a written
explanation of what this parameter describes.
(b) Consider a dimeric protein complex, wherein each subunit of
the dimer can bind to a single substrate molecule. The KD1 for
first binding site is 1 μM and the KD2 for the second binding site
is 10 nM. What is the Hill coefficient for this protein system?
Does it display positive or negative cooperativity? Explain your
answer.