In relation to the Noyes-Whitney equation, explain the dissolution rates obtained for the three formulations.
Posted: Thu Feb 17, 2022 11:12 am
In relation to the Noyes-Whitney equation, explain the
dissolution rates obtained
for the three formulations.
5. Danazol is used for the treatment of endometriosis and fibrocystic breast disease. However it is a poorly soluble drug. To improve its solubility, formulations were either prepared using spray -freezing into liquid (SFL) or by slowly freezing the formulation. Data obtained with these formulations are compared against normal bulk danazol. Formulation Surface area (m²/g) 0.52 Contact angle (wettability) Dissolution rate (ranking from fastest (1) to slowest (2) 2 64.3 48 1 Bulk danazol SFL Slowly frozen formulation 83.06 0.35 47.8 2 In relation to the Noyes-Whitney equation, explain the dissolution rates obtained for the three formulations. (3 marks)
dissolution rates obtained
for the three formulations.
- In Relation To The Noyes Whitney Equation Explain The Dissolution Rates Obtained For The Three Formulations 1 (127.43 KiB) Viewed 58 times