Antibiotic Resistance Develops in a Diabetic Patient Case Study Vancomycin-resistant Staphylococcus aureus (VRSA) was is

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Antibiotic Resistance Develops In A Diabetic Patient Case Study Vancomycin Resistant Staphylococcus Aureus Vrsa Was Is 1 (117.11 KiB) Viewed 98 times

Antibiotic Resistance Develops in a Diabetic Patient Case Study Vancomycin-resistant Staphylococcus aureus (VRSA) was isolated from the exit site of a dialysis catheter in a 40-year-old diabetic with a history of peripheral vascular disease, chronic renal failure, and chronic foot ulcers. A few months earlier, the patient's gangrenous toe had been amputated. Following that surgery, the patient developed bacteremia with methicillin-resistant S. aureus from an infected hemodialysis graft. Vancomycin, rifampin, and graft removal successfully treated the infection. A few months later, when the catheter exit site infection appeared, the area was cultured and the catheter removed, successfully treating the disease. A week later, the patient's chronic foot ulcer again seemed to be infected. Vancomycin-resistant Enterococcus faecalis (VRE) and Klebsiella oxytoca were cultured from the ulcer. The patient recovered after wound care and systemic treatment with trimethoprim/sulfamethoxazole. Analysis of the VRSA isolates revealed the van A gene for vancomycin resistance and the mec A gene for oxacillin resistance. Case Study Directions: For your Case Study Submission, please submit a Microsoft Word or PDF document. There will be one attempt allowed. In your submission, respond to the following question(s): . How do you think the Staphylococcus aureus strain ended up with the gene for vancomycin resistance? . What is one possible mechanism for the genetic transfer of antibiotic resistance from one organism to another? Why would this particular patient be at increased risk for infection with VRSA? .