Answer Happy

1. Which of the following needs to be established before the
search for a lead compound takes place?
Group of answer choices
A. the pharmacophore
B. Structure-activity relationships
C. a bioassay
D. patents
2. What is meant by a lead compound in medicinal chemistry?
Group of answer choices
A. A drug containing the element lead
B. A leading drug in a particular area of medicine
C. A compound that acts as the starting point for drug design
and development
D. A drug which is normally the first to be prescribed for a
particular ailment.
3. During the process of lead generation:
Group of answer choices
A. a drug target is identified
B. high-throughput screening is performed
C. in vivo potency testing is performed
D. phase I studies are completed
4. A bioassay:
A. is the main method used in high throughput screening
B. measures a functional response in a biological tissue
C. measures the binding affinity of an agonist
D. requires the use of radio-labeled ligands
5. A good lead compound in drug discovery will:
A. be extremely polar or lipophilic
B. have structurally related analogues
C. always inhibit biological activity
D. should interact irreversibly with its target