HIV-protease performs post-transcriptional cleavage of new HIV polypeptides for the budding to exit the host cells in li
Posted: Fri Jun 10, 2022 11:29 am
HIV-protease performs post-transcriptional cleavage of new HIV
polypeptides for the budding to exit the host cells in life cycle
continuation.
a) Catalysis of protein chain cleavage by this protease is mediated
by twin Asp-25 residues juxtaposed in the active site. These two
aspartates are said to form a 'catalytic dyad'. One of these
carboxyl groups exhibits an unusually low pKa of 3.3 and the other
displays an unusually high pKa of 5.3. describe how the dyad may
involve the low-barrier hydrogen bonds to perform its function.
polypeptides for the budding to exit the host cells in life cycle
continuation.
a) Catalysis of protein chain cleavage by this protease is mediated
by twin Asp-25 residues juxtaposed in the active site. These two
aspartates are said to form a 'catalytic dyad'. One of these
carboxyl groups exhibits an unusually low pKa of 3.3 and the other
displays an unusually high pKa of 5.3. describe how the dyad may
involve the low-barrier hydrogen bonds to perform its function.