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• pKa of the side chain R-groups: D (3.9), E (4.2), H (6.0)' C (8.3), Y (10.1), K (10.5), and R (12.5). •pka of amino acids a-amino group (9.6) and a-carboxyl group (2.1). • pKa of N-terminal oligopeptide a-amino group (7.4) and C-terminal a-carboxyl group (3.6).
7. If you need to design a drug for treating sickle cell anemia disease, (a) First, what is the cause of sickle cell anemia? (b) For a potential treatment of sickle-cell anemia by drugs targeted to HbS - What molecular properties of Hb S might you suggest as potential targets of drug therapy? (A pharmaceutical company would like to develop drugs to treat people with sickle-cell anemia, what would you advise them?!) Explain your proposed strategy to receive full credits. 8. besides allosteric effectors, list another six factors that may regulate enzyme activity.