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You are studying a human genetic disorder caused by mutations in Gene X, which has 15 exons. You have identified disease
Posted: Thu Jun 09, 2022 11:57 am
by answerhappygod
- You Are Studying A Human Genetic Disorder Caused By Mutations In Gene X Which Has 15 Exons You Have Identified Disease 1 (39.4 KiB) Viewed 145 times
You are studying a human genetic disorder caused by mutations in Gene X, which has 15 exons. You have identified disease alleles in exons 12 and 13 of Gene X that are described in the following table. Mutated Exon Exon Length Mutation in DNA Effect on Gene Expression Disease Phenotype TAC codon (Tyr) to Loss of mRNA Allele 1 12 36 nt. Severe TAA (Stop) Exon skipping Allele 2 12 36 nt. G of 5' splice site to T Mild with no loss of mRNA Allele 3 13 41 nt. G of 5' splice site Exon skipping and to T loss of mRNA Severe What process is causing the loss of mRNA seen for alleles 1 and 3? (2pts) Why is this not seen for allele 2?