Cisplatin is used widely for the treatment of a variety of solid tumours. It forms adducts with cancer cell DNA that, if
Posted: Thu Jun 09, 2022 11:09 am
Cisplatin is used widely for the treatment of a variety of solid tumours. It forms adducts with cancer cell DNA that, if not repaired, can be cytotoxic. Give a short explanation for each of the following observations regarding how Cisplatin targets DNA:
ii. It can form both mono-adducts and bis-adducts (crosslinks).
ii. It can form both mono-adducts and bis-adducts (crosslinks).