Cisplatin is used widely for the treatment of a variety of solid tumours. It forms adducts with cancer cell DNA that, if
Posted: Thu Jun 09, 2022 11:09 am
Cisplatin is used widely for the treatment of a variety of solid tumours. It forms adducts with cancer cell DNA that, if not repaired, can be cytotoxic. Give a short explanation for each of the following observations regarding how Cisplatin targets DNA: i. Its primary site of adduct formation is the N7 atom of purine bases (adenine and guanine).