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(7 marks) The metabolite shown below is an intermediate in the biosynthesis of griseofulvin. There are two possible mode
Posted: Thu Jun 09, 2022 8:13 am
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- 7 Marks The Metabolite Shown Below Is An Intermediate In The Biosynthesis Of Griseofulvin There Are Two Possible Mode 1 (32.37 KiB) Viewed 42 times
(7 marks) The metabolite shown below is an intermediate in the biosynthesis of griseofulvin. There are two possible modes of folding of the polyketide chain to form this product. Write down both of these folding modes and considering the labelling information given below, determine which is the correct mode (and explain why). HO OH 0 9 10 8 OH [1,2-13C]-acetate 5 HO 13C-13C coupling observed between: C1-C6 C4-C5 C13-C14 C9-C10 (Other couplings may have been missed due to poor incorporation). 6 T 13 11 12