P Please help, I just need A, B and C please! Thank you!
Posted: Tue Dec 07, 2021 9:40 pm
P
Please help, I just need A, B and C please! Thank you!
Regulation of the sialyltransferase class of glycosyltransferases is of critical importance as they play key roles in immunoregulation processes, among others. The general mechanism of this enzyme is seen below, featuring the intermediacy of a cytidine-5'-monophospho-N-acetylneuraminic acid (CMP-Neu5Ac) transition state to produce a- sialosides. NH NH2 2 M 2 M* OH HO OH o AcHN 107 con но 2006 R-OH AcHN ZOT co, 20. OH HO OH OR AcHN 207 co HÓ OH OH OH OH CMP-Neu5AC CMP-Neu5Ac transition state alpha-sialoside Recently, a new class of sialyltransferase inhibitors were developed that feature an essential amide moiety of the general structure below: 3 Nat sea OH OH general structure of inhibitors a) Please propose how this new class of sialyltransferase inhibitors might be functioning as an inhibitor (15 pts) b) It was demonstrated that when R Ph, inhibition was 2100 times greater than when R = any size of alkyl chain/ring. Please provide a rationale for these findings (10 pts). c) Based on your answers from a and b. what type of inhibitors have been developed in this study? (5 pts)
- P Please Help I Just Need A B And C Please Thank You 1 (118.15 KiB) Viewed 71 times
Regulation of the sialyltransferase class of glycosyltransferases is of critical importance as they play key roles in immunoregulation processes, among others. The general mechanism of this enzyme is seen below, featuring the intermediacy of a cytidine-5'-monophospho-N-acetylneuraminic acid (CMP-Neu5Ac) transition state to produce a- sialosides. NH NH2 2 M 2 M* OH HO OH o AcHN 107 con но 2006 R-OH AcHN ZOT co, 20. OH HO OH OR AcHN 207 co HÓ OH OH OH OH CMP-Neu5AC CMP-Neu5Ac transition state alpha-sialoside Recently, a new class of sialyltransferase inhibitors were developed that feature an essential amide moiety of the general structure below: 3 Nat sea OH OH general structure of inhibitors a) Please propose how this new class of sialyltransferase inhibitors might be functioning as an inhibitor (15 pts) b) It was demonstrated that when R Ph, inhibition was 2100 times greater than when R = any size of alkyl chain/ring. Please provide a rationale for these findings (10 pts). c) Based on your answers from a and b. what type of inhibitors have been developed in this study? (5 pts)