2. The final product of the following multistep synthesis is a derivative of tetramethylrhodamine (TMR). TMR's are a cla
Posted: Thu Dec 02, 2021 6:51 am
2. The final product of the following multistep synthesis is a derivative of tetramethylrhodamine (TMR). TMR's are a class of fluorophores, which are a type of compound that emits light upon absorption of higher energy light. Fluorophores typically contain large, conjugated pi systems, and this compound is no exception. Fill in the boxes of the multistep synthesis scheme, ignoring stereochemistry. Then show the curved arrow mechanism for the final step of the synthesis scheme. CI- OOO Фо NH; (PCC) 2. H20 (workup) Resonance- assisted dehydration HCI HO Mechanism for resonance-assisted dehydration (last step): Pictures from the last step of the synthesis: Before HCl: During HCl addn: After HCl addn: After purification: