suntony niazole P- acetamidobenzenesulfonamide 3 in dry acetonitrile using anhydrous K2CO3 resulted in a light brown sol

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Suntony Niazole P Acetamidobenzenesulfonamide 3 In Dry Acetonitrile Using Anhydrous K2co3 Resulted In A Light Brown Sol 1 (46.76 KiB) Viewed 109 times

suntony niazole P- acetamidobenzenesulfonamide 3 in dry acetonitrile using anhydrous K2CO3 resulted in a light brown solid, which was confirmed to be the desired intermediate 3 based on NMR and MS data Scheme 2. Scheme 2. Synthesis of Sulfathiazole (New Method) dry CH CN K.co, -NHCOCH3 NH of + more oto -NHCOCH, нсі reflux. 30 min reflux, 25 min Olon The hydrolysis of the p-acetamido group of intermediate 3 by aqueous acid followed by neutralization with solid sodium bicarbonate simplified the neutralization step. Use of solid sodium bicarbonate for the neutralization step eliminates the complications of over acidification as well as over dilution leading to poor yield and lower quality product. This modified route for the synthesis of sulfathiazole is shown in Scheme 2. The only concern was if the heterocyclic ring would be stable to acid hydrolysis conditions in Scheme 2