Transcription factor p53 recognises different classes of DNA binding sites with different nucleotide sequences. One clas
Posted: Wed May 25, 2022 7:11 am
Transcription factor p53 recognises different classes of DNA
binding sites with different nucleotide sequences. One class of
binding sites is preferentially associated with activating response
elements increasing gene expression (Figure 1A). A second class is
associated with repressive response elements decreasing gene
expression (Figure 1B).
Figure 1. Sequence
logo representation of p53 binding sites that act as activating (A)
and repressive response elements (B).
1. Explain the meaning of the
“sequence logo” representation of transcription factor binding
motifs, and summarise the differences between sequence logos shown
in panels A and B
2. Taking into account the information
in Figure 1, suggest a hypothesis to explain how p53 regulates the
fate of the cell using different classes of binding
sites.
A Activating CAT CESS CATC3. Repressing • 1 C G C O CG G GG - - - = - 2 5' 3'
binding sites with different nucleotide sequences. One class of
binding sites is preferentially associated with activating response
elements increasing gene expression (Figure 1A). A second class is
associated with repressive response elements decreasing gene
expression (Figure 1B).
- Transcription Factor P53 Recognises Different Classes Of Dna Binding Sites With Different Nucleotide Sequences One Clas 1 (32.06 KiB) Viewed 22 times
logo representation of p53 binding sites that act as activating (A)
and repressive response elements (B).
1. Explain the meaning of the
“sequence logo” representation of transcription factor binding
motifs, and summarise the differences between sequence logos shown
in panels A and B
2. Taking into account the information
in Figure 1, suggest a hypothesis to explain how p53 regulates the
fate of the cell using different classes of binding
sites.
A Activating CAT CESS CATC3. Repressing • 1 C G C O CG G GG - - - = - 2 5' 3'