could you please explain the process how clavanic acid produce from the family of clavams ?

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could you please explain the process how clavanic acid produce from the family of clavams ?

Could You Please Explain The Process How Clavanic Acid Produce From The Family Of Clavams 1 (37.73 KiB) Viewed 11 times

Could You Please Explain The Process How Clavanic Acid Produce From The Family Of Clavams 2 (37.73 KiB) Viewed 11 times

CO₂H Clavulanic acid مليط OH Ax 6 R=CO₂H 7 R=CH₂OH 8 R=CH₂OCHO 9 RACH, CHÍNH, COH 10 R=CH₂CH₂OH 11 R=CH₂CHCH(OH)CO₂H 12 R=CH₂CH(OH)CHCO₂H NHCOCHINH, CHM NH COCHINH, CHME CO₂H H NH H NH₂ OH CO₂H 1 NHR BA HO CO₂H 2 Clavaminic acid R = H 3 R COCH₂ H₂N. OH 4 R=COCH₂NHCOCH, OH 5 R=COCH₂NH₂ Tú 17188 Clavamycin A Clavamycin B Figure 1. Clavulanic acid (CA) and its b-hydroxy propionyl derivative (isolated as its benzyl ester) are unusual among the family of naturally occurring clavams because they have the (5R)-ring junction stereochemistry. O NHR 13 R=COCH(NH₂)CH(OH)CH(OH)CH₂NH₂, Clavamycin C 14 R L-Valyl: Clavamycin D 15 R-L-Alanyl: Clavamycin E 16 R=L-N-Acetylornithyl; Clavamycin F HỌ H HO HO CO₂H сон NH NH CO₂H HO. H₂N HN CO₂H