Sar1 GTPase plays an important role in COPII coat formation. Scientists generated a Sar1 GTPase mutant, in which the GTP
Posted: Mon May 23, 2022 9:01 am
Sar1 GTPase plays an important role in COPII coat formation. Scientists generated a Sar1 GTPase mutant, in which the GTPase activity is lost. How this mutant would affect the COPII-mediated transport?
No effect would be observed.
COPII-coated vesicles can’t form at all.
COPII-coated vesicles can form, but the coat can’t be disassembled and thus the vesicles can’t fuse with the target membrane.
COPII-coated vesicles can form normally, but the coat can’t be disassembled. However, the coated vesicles can still dock and fused with the target membrane.
No effect would be observed.
COPII-coated vesicles can’t form at all.
COPII-coated vesicles can form, but the coat can’t be disassembled and thus the vesicles can’t fuse with the target membrane.
COPII-coated vesicles can form normally, but the coat can’t be disassembled. However, the coated vesicles can still dock and fused with the target membrane.