The following Synthetic screme should make cyclic tetrapeptide, but it has some errors that prevents its Success. Please
Posted: Mon May 23, 2022 7:04 am
The following Synthetic screme should make cyclic tetrapeptide, but it has some errors that prevents its Success. Please help point out 4 of those errors & give a brief explanation as to why they don't work and provide 1 solution on how to fix one of those errors
B Boc J tBo Fmoc HN H₂, Pd FmocHN E JOH NB₂ NIL 0 HATU, DIPEA tBu Bn -->> 6 Bu FMOCHN ļo DCC <- HATU DIPEA -> ON Bu NaOH fle FmocHN OH Bn TIFALA₂ ---- OH H₂N TFA, CH₂)₂ 32 NH date
B Boc J tBo Fmoc HN H₂, Pd FmocHN E JOH NB₂ NIL 0 HATU, DIPEA tBu Bn -->> 6 Bu FMOCHN ļo DCC <- HATU DIPEA -> ON Bu NaOH fle FmocHN OH Bn TIFALA₂ ---- OH H₂N TFA, CH₂)₂ 32 NH date