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5. Metallo-beta-lactamase, a dinuclear Zn(II) enzyme, can hydrolyze certain antibiotics. The following compounds (4# and
Posted: Mon May 23, 2022 7:03 am
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- 5 Metallo Beta Lactamase A Dinuclear Zn Ii Enzyme Can Hydrolyze Certain Antibiotics The Following Compounds 4 And 1 (85.2 KiB) Viewed 13 times
5. Metallo-beta-lactamase, a dinuclear Zn(II) enzyme, can hydrolyze certain antibiotics. The following compounds (4# and 5#) are effective inhibitors of this enzyme. Describe and explain their modes of action in words as well as by drawing the potential molecular structures. D124 CO₂H H122 HO₂C CO₂H HS HO H120 Zn1 H189 H250 C208 Active site 4# HN. HO₂C 5# NH₂ (12 marks)