H₂N. tBu tBu Bn NaOH Boc Boc OH Вос. ***** HATU, Bn DIPEA Starting Material Reagents 1 Intermediate 1 Reagent 2 (SM) (R1
Posted: Mon May 23, 2022 6:06 am
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contains multiple errors that will prevent the efficient synthesis
of the
final product. Find 4 issues with this scheme. List and draw
it out with an explanation why. Then fix 1 of the 4 issues and draw
its solution (also explain why).
H₂N. tBu tBu Bn NaOH Boc Boc OH Вос. ***** HATU, Bn DIPEA Starting Material Reagents 1 Intermediate 1 Reagent 2 (SM) (R1) (11) (R2) NH₂ OH FmocHN H₂N you Bn NH₂ Intermediate 5 (15) Intermediate 4 (14) H₂, Pd Reagents 6 (R6) .OH OH NH₂ Intermediate 6 (16) FmocHN FmocHN IZ ZIO Bn OH DCC Reagents 5 (R5) HATU, DIPEA FmocHN Reagents 7 (R7) NH Intermediate 7 (17) ZI Bn OH tBu 。 ZI OH Bn Intermediate 2 (12) TFA, CH₂Cl₂ Boc. Reagents 4 (R4) TFA, CH₂Cl₂ Reagents 8 (R8) H₂N H₂N DIPEA Reagents 3 (R3) O= ZIO Bn Intermediate 3 (13) OH ΝΗ Final Product Bn OH