PLEASE HELP ALL ONE PROBLEM
Posted: Sun May 22, 2022 8:19 pm
PLEASE HELP ALL ONE PROBLEM
1. Consider the following mechanism: Coro Choo ON OM CHOR HOO LS COM OH broj fios CORO ICO орн borot OPO a. (2 pts) What kind of reaction is occurring during this step of glycolysis? b. (2 pts) What metabolite is in Box 1? C. (2 pts) What metabolite is in Box 2? d. (2 pts) What metabolite is in Box 3?
e. (2 pts) What enzyme catalyzes this reaction? f. (2 pts) Circle and label one place on the mechanism where covalent catalysis is occurring. g. (4 pts) Suggest an amino acid that could fill the role of residue "A" in the mechanism above and draw its structure at pH 7.4. h. (4 pts) Suggest an amino acid that could fill the role of residue "B" in the mechanism above and draw its structure at pH 7.4. i. (2 pts) Under standard conditions this reaction is unfavorable (DGC = 23.8 kJ/mol). What conditions in the cell allow for the actual free energy change to be lower (DG » 0), making the reaction readily reversible? Explain your answer.
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e. (2 pts) What enzyme catalyzes this reaction? f. (2 pts) Circle and label one place on the mechanism where covalent catalysis is occurring. g. (4 pts) Suggest an amino acid that could fill the role of residue "A" in the mechanism above and draw its structure at pH 7.4. h. (4 pts) Suggest an amino acid that could fill the role of residue "B" in the mechanism above and draw its structure at pH 7.4. i. (2 pts) Under standard conditions this reaction is unfavorable (DGC = 23.8 kJ/mol). What conditions in the cell allow for the actual free energy change to be lower (DG » 0), making the reaction readily reversible? Explain your answer.