7. In the brown adipose tissue (BAT) in the newborns, transmembrane proton gradient is used not only to produce ATP, but
Posted: Wed May 18, 2022 11:44 am
7. In the brown adipose tissue (BAT) in the newborns,
transmembrane proton gradient is used not only to produce ATP, but
to keep the newborns warm. The mitochondria of BAT have a unique
protein in their inner membrane — thermogenin, also called the
uncoupling protein 1 (UCP1). Explain the role of UCP1 in
thermoregulation. For the answer: a) draw the scheme of the ETC and
explain how the electrochemical gradient is generated during the
electron transport; b) describe the mechanisms of uncoupling of
oxidative phosphorylation by UCP1; c) compare the changes in the
transmembrane proton gradient after the action of inhibitors of the
respiratory chain (including rotenone, antimycin A, cyanide, carbon
monoxide) and the uncoupling agents
transmembrane proton gradient is used not only to produce ATP, but
to keep the newborns warm. The mitochondria of BAT have a unique
protein in their inner membrane — thermogenin, also called the
uncoupling protein 1 (UCP1). Explain the role of UCP1 in
thermoregulation. For the answer: a) draw the scheme of the ETC and
explain how the electrochemical gradient is generated during the
electron transport; b) describe the mechanisms of uncoupling of
oxidative phosphorylation by UCP1; c) compare the changes in the
transmembrane proton gradient after the action of inhibitors of the
respiratory chain (including rotenone, antimycin A, cyanide, carbon
monoxide) and the uncoupling agents