The Robinson annulation is a combination of two carbonyl coupling reactions, the Michael reaction and the intramolecular
Posted: Wed May 18, 2022 11:24 am
The Robinson annulation is a combination of two carbonyl coupling reactions, the Michael reaction and the intramolecular aldol condensation The most common partners in the reaction are a nucleophilic donor (such as a cyclic ketone, a B-keto ester, an enamine, or a B-diketone) and an o,B-unsaturated ketone acceptor. The product is a substituted 2-cyclohexenone derivative, Draw the structures of the nucleophilic cyclic ketone and the o, B-unsaturated ketone acceptor that were combined in a Robinson annulation to give the following product: 998) 998) la 03. Y 0 0 - Chamboodle Cheb Nucleophilic donor 0,8-Unsaturated ketone acceptor