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You are dealing with a drug exhibiting dissolution rate limited absorption. The drug is available as a tablet dosage for
Posted: Tue May 17, 2022 10:10 pm
by answerhappygod
- You Are Dealing With A Drug Exhibiting Dissolution Rate Limited Absorption The Drug Is Available As A Tablet Dosage For 1 (178.94 KiB) Viewed 42 times
You are dealing with a drug exhibiting dissolution rate limited absorption. The drug is available as a tablet dosage form. One patient ("Patient A") took one tablet with 50 mL of water, while a second patient ("Patient B") also took one tablet, but with 500 mL of water. The bioavailability (fraction of drug reaching systemic circulation) was much higher for Patient B. Explain this observation, based on the Noyes-Whitney equation. (no more than 100 words)