A). You have a culture of an epithelial-like cell line that was isolated from a patient who had metastatic breast cancer
Posted: Tue May 17, 2022 6:53 pm
A). You have a culture of an epithelial-like cell line that was
isolated from a patient who had metastatic breast cancer. The cells
grow well in culture and their morphology is very epithelial-like:
they form junctions and grow in islands. Interestingly when these
cells are implanted into a nude mouse, they look quite different.
They are much more motile and have a spindle shaped “mesenchymal
appearance”. What is the name of this phenomenon? What are
some potential reasons why the cells only look mesenchymal when in
an animal and not in pure culture?
isolated from a patient who had metastatic breast cancer. The cells
grow well in culture and their morphology is very epithelial-like:
they form junctions and grow in islands. Interestingly when these
cells are implanted into a nude mouse, they look quite different.
They are much more motile and have a spindle shaped “mesenchymal
appearance”. What is the name of this phenomenon? What are
some potential reasons why the cells only look mesenchymal when in
an animal and not in pure culture?