Answer Happy

13. Which of the following could generate a neoantigen? a. “Coding" mutations that change amino acids in proteins. b. Methylation of a promoter, causing repression of a normally active gene. C. Histone acetylation, causing activation of an otherwise silent gene. d. Chromosomal translocation. e. Chromosome deletion 14. What are major reasons we cannot, currently, use genome editing in patients to repair the cancer-causing mutations in the cancer cells back to normal? a. We cannot tell which mutations to repair. b. Genome editing is imprecise, causing a lot of off-target mutations, and therefore runs a high risk of causing new cancers or causing existing cancers to get worse. c. We cannot effectively repair all of the cancer cells in a patient. d. Ethical restrictions prevent genome editing procedures from entering pre-clinical trials. e. The repaired mutations automatically revert back to the mutant form very quickly, so the repair is short-lived.