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(b) Answer all sections (0) - (V). HO NH2 H3C 841 Сн, о. ОН HN 没 НО. OH но O COOH N-N 0 Penicillin G HN NH HOOC WIN HyN OH OH Vancomycin HO (1) Draw the structure of the disaccharide repeating unit of the bacterial cell wall peptidoglycan including the peptide side chain (not crosslinked). (14) (ii) What are the respective drug targets for the antibiotics Penicillin G and Vancomycin (structures see above)? (8) (iii) Give a major reason for resistance against Penicillin G and explain how this has been addressed to develop new penicillins active also against Penicillin G resistant bacterial strains? (15) (iv) Bacteria resistant to Vancomycin often have a mutation in the peptide side chain of the cell wall peptidoglycan. Which? (5) (v) Discuss how this mutation makes the bacterial strains Vancomycin-resistant but still viable. (8)