Answer Happy

Question 34-37 are based on the pharmacodynamics study results of three chemical analogs for the same disease shown below. Dashed lines: efficacy curve; solid lines: toxicity curves (lethality of cultured fibroblasts); X-axis, concentration in uM. Compound A Compound B Compound C 0.1 1 10 50 100 0.1 1 10 50 100 0.1 1 10 50 100 34. Which compound has the lowest toxicity? a. Compound A. b. Compound B. c. Compound C. d. They have the same toxicity since they are analogs. 35. Which compound has the highest therapeutic index (TI=TD50/EDso)? a. Compound A. b. Compound B. c. Compound C. d. They have the same TI. 36. If they are all approved by FDA, which compound needs close monitoring? a. Compound A. b. Compound B. 4 Compound C. d. Doesn't matter. 7 37. Many alkylating drugs typically show a result like compound A. Why is that? a. Because they have high non-specific toxicity. b. Because they usually have low efficacy. c. Because they only inhibit cancer growth for short time. d. Because they get excreted out of body soon.