Answer Happy

Question 2: A Case of Parkinson's Disease. (25 points total) Your research team decided to test the effect of a novel molecular activator on dopamine expressing neuron cell survival in Parkinson's disease. In addition, your team also monitored levels of a novel transcription factor B mRNA levels in micromolar (UM) levels. 100 neurons were observed per group and condition. Evaluate the data below: Group Condition Average Percentage of Average transcription live neurons (%) factor B mRNA levels (UM) Normal dopamine No activator added 98% 50 MM expressing neurons 45 UM Activator present at 50 85% UM Parkinson's disease No activator added 25% affected dopamine expressing neurons 10 M 15 UM Activator present at 50 75% UM Part 2C: Your research team wants to test the following novel hypothesis: Novel transcription factor III is required for inhibiting dopamine expressing neuron cell survival. How would you design your experiment? Include appropriate control and experimental groups. In addition, what outcomes would you measure for? (10 points; 5 points for appropriate controls; 5 points for outcome(s) to measure from experimental plan) (10 points).