Provide a detailed mechanism to account for the base catalyzed Robinson annulation reaction between 1,3-diphenylpropam-2
Posted: Tue May 17, 2022 9:54 am
Provide a detailed mechanism to account for the base catalyzed
Robinson annulation reaction between 1,3-diphenylpropam-2-one (5)
and methyl vinyl ketone (6,but-3-en-2-one) to give
3-methyl-2,6-diphenylcyclohec-2-enone (7). This process involves an
initial Michael reaction followed by an intramolecular Aldo’s
condensation reaction. Show curly arrows for bond making and
breaking in each step as well as the structures in the
mechanism.
Robinson annulation reaction between 1,3-diphenylpropam-2-one (5)
and methyl vinyl ketone (6,but-3-en-2-one) to give
3-methyl-2,6-diphenylcyclohec-2-enone (7). This process involves an
initial Michael reaction followed by an intramolecular Aldo’s
condensation reaction. Show curly arrows for bond making and
breaking in each step as well as the structures in the
mechanism.