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(c) Answer all sections () - (v) The structures of three anti-viral drugs, AZT and emtricitabine against HIV infections
Posted: Tue May 17, 2022 9:02 am
by answerhappygod
- C Answer All Sections V The Structures Of Three Anti Viral Drugs Azt And Emtricitabine Against Hiv Infections 1 (229.61 KiB) Viewed 61 times
(c) Answer all sections () - (v) The structures of three anti-viral drugs, AZT and emtricitabine against HIV infections and aciclovir against herpes infections are shown below. O= NH NH NH НО, HO NH2 O HO N3 AZT Aciclovir Emtricitabine (0) What are the respective drug targets for AZT, emtricitabine, and aciclovir and what are the modes of action of the drugs? (10) (ii) All three compounds are prodrugs, draw the corresponding active drug of one of the three prodrugs. (10) (iii) AZT was the first licensed anti-HIV drug but is now rarely used, while Emtricitabine is used frequently. Why? (10) (iv) The drug target of acyclovir is a human enzyme, how can it then be an anti-viral drug? (10) (v) Why do viruses (and especially HIV) quite quickly acquire resistance to drugs and how is this problem addressed in the treatment of AIDS patients. (10) A