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(c) Answer all sections (1) - (iv). HO OH OH AcHN HO HO COOH Neuraminic acid (NeuAc) Two anti-flu virus drugs, Relenza a
Posted: Tue May 17, 2022 9:00 am
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- C Answer All Sections 1 Iv Ho Oh Oh Achn Ho Ho Cooh Neuraminic Acid Neuac Two Anti Flu Virus Drugs Relenza A 1 (125.99 KiB) Viewed 66 times
(c) Answer all sections (1) - (iv). HO OH OH AcHN HO HO COOH Neuraminic acid (NeuAc) Two anti-flu virus drugs, Relenza and Tamiflu, have been developed using the natural substrate Neuraminic acid (NeuAc) as template. (0) What is the drug target for both Relenza and Tamiflu? (5) (ii) Draw the structure of Relenza. (10) (iii) Discuss the rationale behind the structural changes introduced into the drug Relenza as compared to the natural substance NeuAc. (15) (iv) Tamiflu was developed from Relenza. Give the structure of Tamiflu and discuss the rationale behind the structural changes made as compared to Relenza. (20)