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Done MAIN_2022_4LM... ☆ xa Answer any FOUR questions. Please answer each question in a separate word document. Question 1 It has been observed that an active pharmaceutical ingredient becomes less soluble in water as it changes to a less soluble polymorph in response to pressure. a) Discuss a suitable granulation process for this drug. b) Wet granulation usually involves a drying step to reduce the amount of moisture in the formulation. Discuss how drying is achieved using a fluidised bed dryer and its advantages over an oven tray dryer. c) Discuss the impact of the moisture content of air on a drying process. This should include how this could be controlled to ensure drying efficiency Question 2 In a revision session for the topic of 'Kinetics' in the module 'Drugs and Medicines', students were given the following Figure and asked whether the data presented was consistent with zero, first or second order kinetics. 5 61 1 0 0 5 20 25 10 15 time / min Figure 1. Concentrations (mm) of analyte X as a function of time. Their answer was that the reaction illustrated in Figure 1 follows zero order kinetics. Briefly explain reaction orders and whether you agree or not with the statement above, appropriately justifying your answer and using Equations as required. Page 2 of 4 4LMS0213 Drugs and Medicines O Reply...