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Kaplan-Maer limit sahmator/cox ma problem A randomized study testo a form of mushga tone thirapy after surgery for Breast cancer vs. current Standard of care. The main outcomwwo wo Survive cach panent has covertoo Treatments nu treatment O standard of Cad geneh munten: genel gene 2 or normalt The effect of new therapy may suffer the mutahun status 10 Write down the cos mides for predicting curva from 1x, metata, and TX by mutant interact Including a dehin bn of the coeficients and their rele muhto swwwel State important to (2) Desembe the most peopriate hypotheses test ter whether the trache Hermserau repoured in the modet. Stale thou hypothesen sth Coffunts. How the teste statue de celulelor? in my or tror model corrente what would be the leg hazard rate of spent w/_*/ and multot gen 2 * peties TX 26 aad outent normal? What would De we heart rate Please produse in your owte. Thank you

Kaplan-Meier limit ishmeter/cox model problem A randomized study tests a form of investigational therapy after surgery for Breast cancer vs. current standard of care . The main outcomu w diseas survival Each patient has a covariates: Treatment: 1 = new treatment or standard of care. genetic mulatan: genel gene? or normal (reuther The effect of new therapy may differ mutation present) w Hu mutahun status 2 + o Wnite down the cox meded for predicting survival from Tx , mutation, and Tx by mutant interaction Including a definition of the coefficients and their rela hunha to survival. State important assumptions. (2) Describe the most appropriate hypothess test for whether the interaction terms may required in the modet. State the sull hypothes in terms of the coefficients. How the test statistic be calculated? & in terms of the interaction model coffements, what would be the log hazard rate of a patent w/ txal and mutuo t - gen 2 to 4 patient WITX=6 and mutant normal? What would be the hazard rates? please provide steps in your answer. Thank you.