4. a) Mr. TG is prescribed Furosemide 2mg/kg/dose po od according to the tablet dosage form. The bioavailability factor
Posted: Mon May 09, 2022 3:42 pm
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4. a) Mr. TG is prescribed Furosemide 2mg/kg/dose po od according to the tablet dosage form. The bioavailability factor of a 40mg tablet is 0.67. The senior Pharmacist indicated to you to use the Furosemide oral solution of 40mg/5mL. If the bioavailability factor of the oral solution is 0.8, calculate the dose of the oral solution which is equivalent to the tablet. (4 marks b) What is the volume of 10% dextrose solution should be added to 100mL of 25% dextrose solution in order to prepare a 15% dextrose solution for infusion? [1 mark] c) If the hospital has the Micro drip sets of 60 drops/mL, how long will it take to deliver a volume of 200mL of Dextrose compared to if the standard (Macro) drip sets of 15 drops/mL, if in each case one drop is to be administered per second? [1 mark] d) The dissociation constant of ethanolamine is 3.6 * 10 at 25°C. Calculate its pk, value. 12 marks] e) Calculate the molar ratio of salt to acid that would be required to prepare a buffer solution with a a pH of 5.6. The pk value of the acid is 3.7 at 25°C. (2 marks]
4. a) Mr. TG is prescribed Furosemide 2mg/kg/dose po od according to the tablet dosage form. The bioavailability factor of a 40mg tablet is 0.67. The senior Pharmacist indicated to you to use the Furosemide oral solution of 40mg/5mL. If the bioavailability factor of the oral solution is 0.8, calculate the dose of the oral solution which is equivalent to the tablet. (4 marks b) What is the volume of 10% dextrose solution should be added to 100mL of 25% dextrose solution in order to prepare a 15% dextrose solution for infusion? [1 mark] c) If the hospital has the Micro drip sets of 60 drops/mL, how long will it take to deliver a volume of 200mL of Dextrose compared to if the standard (Macro) drip sets of 15 drops/mL, if in each case one drop is to be administered per second? [1 mark] d) The dissociation constant of ethanolamine is 3.6 * 10 at 25°C. Calculate its pk, value. 12 marks] e) Calculate the molar ratio of salt to acid that would be required to prepare a buffer solution with a a pH of 5.6. The pk value of the acid is 3.7 at 25°C. (2 marks]