Consider the following model to explore how bronchoconstriction in asthmatic or normal airways may result in smooth musc
Posted: Mon May 09, 2022 2:31 pm
Consider the following model to explore how bronchoconstriction
in asthmatic or normal airways may result in smooth muscle
shortening. The airway smooth muscle is assumed to be confined to a
band surrounding the inner tissues of the wall (submucosa, mucosa –
see diagram).
Consider constriction of the airways resulting from a 25%
reduction in smooth muscle length. Derive an expression for
the change in airway radius:
Assume the wall area inside the smooth muscle,
A_{w}, remains constant and that the circular geometry
of the airway lumen and the smooth muscle ring is maintained.
---------------------------------------------
Use Poiseuille's equation to aid in the formulation of this
expression:
TL r sm Smooth Muscle Submucosa
1,1 1,0
ul R = πY4
in asthmatic or normal airways may result in smooth muscle
shortening. The airway smooth muscle is assumed to be confined to a
band surrounding the inner tissues of the wall (submucosa, mucosa –
see diagram).
Consider constriction of the airways resulting from a 25%
reduction in smooth muscle length. Derive an expression for
the change in airway radius:
Assume the wall area inside the smooth muscle,
A_{w}, remains constant and that the circular geometry
of the airway lumen and the smooth muscle ring is maintained.
---------------------------------------------
Use Poiseuille's equation to aid in the formulation of this
expression:
TL r sm Smooth Muscle Submucosa
1,1 1,0
ul R = πY4