A study estimated the effect of 3-drug ART treatments versus 4-drug ART treatments for HIV-infected patients on the risk
Posted: Mon May 09, 2022 12:59 pm
A study estimated the effect of 3-drug ART treatments versus
4-drug ART treatments for HIV-infected patients on the risk of
virologic failure in the first 144 weeks. Virologic failure is a
(binary) outcome of interest in HIV clinical trials, with
treatments intended to prevent virologic failure. A table with
results of some univariate analyses (each result representing one
analysis with one predictor) and a table with results from a
multivariate analysis (one analysis with the predictors mentioned)
is posted below.
b. In the multivariate model, test whether viral load
significantly predicts virologic failure. Use a significance level
of 0.08.*
c. In the univariate model, test whether viral load
significantly predicts virologic failure. Use a significance level
of 0.08.*
d. Do your results from b. and c. agree with each other? If not,
what explains the difference?*
Table 1: Univariate analyses. Events in weeks 0 – 144. Estimated Odds Ratios (95%-confidence intervals), and p-values for baseline covariates. Baseline covariate Virologic Failure (VF) ART: 4 drugs (vs 3 drugs) sex: male (vs female) age (per 10 years older) age < 30 injection drug use: ever (vs never) black non-Hispanic! Hispanic sqrt2 CD4 count (per 3 units higher)3 viral load (per log10 copies/ml higher) 0.76 (0.52,1.08), p=0.12 1.02 (0.64,1.76), p=0.90 0.97 (0.79,1.18), p=0.81 1.04 (0.65,1.57), p=0.89 2.21 (1.23,3.75), p=0.01 2.17 (1.44,3.39), p<0.001 1.13 (0.66,1.91), p=0.66 0.96 (0.88,1.05), p=0.38 1.25 (0.96,1.63), p=0.10 1 3 For example, a CD4 count of 100 versus 49, versus white/other, model with all race/ethnicities included. 2 square root. 294 versus 200, or 643 versus 500 cells/mm.
Table 2: Multivariate analysis. Events in weeks 0 – 144. Estimated Odds Ratios (95%-confidence intervals), and p-values for baseline covariates. Baseline covariate Virologic Failure (VF) ART: 4 drugs (vs 3 drugs) age (per 10 years older) black non-Hispanic? viral load (per log10 copies/ml higher) injection drug use: ever (vs never) ART*injection drug use 0.94 (0.62,1.43), p=0.78 0.93 (0.74,1.16), p=0.53 2.11 (1.43,3.19), p<0.001 1.29 (0.99,1.73), p=0.06 3.75 (1.64,9.44), p=0.003 0.32 (0.07,1.09), p=0.07 1 versus white/other/Hispanic.
4-drug ART treatments for HIV-infected patients on the risk of
virologic failure in the first 144 weeks. Virologic failure is a
(binary) outcome of interest in HIV clinical trials, with
treatments intended to prevent virologic failure. A table with
results of some univariate analyses (each result representing one
analysis with one predictor) and a table with results from a
multivariate analysis (one analysis with the predictors mentioned)
is posted below.
- A Study Estimated The Effect Of 3 Drug Art Treatments Versus 4 Drug Art Treatments For Hiv Infected Patients On The Risk 1 (121.23 KiB) Viewed 23 times
- A Study Estimated The Effect Of 3 Drug Art Treatments Versus 4 Drug Art Treatments For Hiv Infected Patients On The Risk 2 (85.79 KiB) Viewed 23 times
significantly predicts virologic failure. Use a significance level
of 0.08.*
c. In the univariate model, test whether viral load
significantly predicts virologic failure. Use a significance level
of 0.08.*
d. Do your results from b. and c. agree with each other? If not,
what explains the difference?*
Table 1: Univariate analyses. Events in weeks 0 – 144. Estimated Odds Ratios (95%-confidence intervals), and p-values for baseline covariates. Baseline covariate Virologic Failure (VF) ART: 4 drugs (vs 3 drugs) sex: male (vs female) age (per 10 years older) age < 30 injection drug use: ever (vs never) black non-Hispanic! Hispanic sqrt2 CD4 count (per 3 units higher)3 viral load (per log10 copies/ml higher) 0.76 (0.52,1.08), p=0.12 1.02 (0.64,1.76), p=0.90 0.97 (0.79,1.18), p=0.81 1.04 (0.65,1.57), p=0.89 2.21 (1.23,3.75), p=0.01 2.17 (1.44,3.39), p<0.001 1.13 (0.66,1.91), p=0.66 0.96 (0.88,1.05), p=0.38 1.25 (0.96,1.63), p=0.10 1 3 For example, a CD4 count of 100 versus 49, versus white/other, model with all race/ethnicities included. 2 square root. 294 versus 200, or 643 versus 500 cells/mm.
Table 2: Multivariate analysis. Events in weeks 0 – 144. Estimated Odds Ratios (95%-confidence intervals), and p-values for baseline covariates. Baseline covariate Virologic Failure (VF) ART: 4 drugs (vs 3 drugs) age (per 10 years older) black non-Hispanic? viral load (per log10 copies/ml higher) injection drug use: ever (vs never) ART*injection drug use 0.94 (0.62,1.43), p=0.78 0.93 (0.74,1.16), p=0.53 2.11 (1.43,3.19), p<0.001 1.29 (0.99,1.73), p=0.06 3.75 (1.64,9.44), p=0.003 0.32 (0.07,1.09), p=0.07 1 versus white/other/Hispanic.