Blood Film Drug 1. You are designing a new device (Blue box) to deliver a drug to the blood. You can consider that the b
Posted: Thu May 05, 2022 5:41 pm
Blood Film Drug 1. You are designing a new device (Blue box) to deliver a drug to the blood. You can consider that the blood is falling down as a laminar liquid film. The soluble pro-drug (A) is released from the device and then can be activated to drug (A*) by enzyme (E) into the blood. You can assume that the concentration of the enzyme in the blood is constant, the concentration of the pro-drug (A) at the device- blood interface is same as its concentration in the device CAO. Suppose the system has reached the steady state. delivery device Z E A→A* (A). The velocity profile of the fluid. Step 1. Use the Naiver-Stokes equations or Momentum shell balance to derive the simplified form of the conservation of momentum equation. List ALL assumptions. Step 2. Write all applicable boundary conditions. Step 3. Solve for the velocity profile of the fluid as a function of position and w: (B). The concentration profile of the pro-drug (A) and drug (A*) Step 1. Write the simplified conservation of mass equation that best fits this situation. Step 2. Write appropriate boundary conditions. Air