For problems 1-8, use the following data (as needed): MW of drug = 150 Ka (for therapeutically-relevant target) = 25 uM

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For Problems 1 8 Use The Following Data As Needed Mw Of Drug 150 Ka For Therapeutically Relevant Target 25 Um 1 (96.56 KiB) Viewed 41 times

For problems 1-8, use the following data (as needed): MW of drug = 150 Ka (for therapeutically-relevant target) = 25 uM (0.025 mM) Volume of distribution 50 L Bioavailability (enteral vs. parenteral) = 0.6 Clearance (total) = 250 ml/min (assume this value is constant for any non-zero plasma concentration). Fraction not bound in plasma (f) = 0.1 Glomerular filtration rate (measured w/ creatinine) = 120 ml/min Tubular secretion and resorption = 0 Total renal blood/plasma flow = 1.0 L/min Hepatic blood flow (Qh) = 1.5 L/min 1) What loading dose (mass) of drug X should be administered (by IV bolus) to the patient to achieve an "initial" plasma concentration (Co) of 50 µg/ml (50 micrograms per milliliter)? 2) At the concentration indicated above (50 ug/ml), what is the MOLAR concentration of FREE drug in plasma? 3) Assuming the plasma concentration calculated above (part 2) is the same as the (free) concentration in the vicinity of the receptor, what fraction of the drug receptor should be occupied? 4) Assume that the liver is the only organ other than the kidney involved in elimination of the drug. Use the data provided to estimate the hepatic Extraction ratio (E). 5) What is the calculated half-life of the drug in the patient? 6) What infusion rate (mass of drug/min, administered IV) should be used to achieve/maintain a steady-state level of 50 ug/ml? 7) If the patient takes a single tablet orally every 8 hours, how much drug (mass) should each tablet contain to maintain that steady state level (50 ug/ml)?