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2. As we talked about in class, electron-deficient aromatic halides undergo nucleophilic aromatic substitution (NAS) rea
Posted: Mon May 02, 2022 5:59 pm
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- 2 As We Talked About In Class Electron Deficient Aromatic Halides Undergo Nucleophilic Aromatic Substitution Nas Rea 1 (62.99 KiB) Viewed 30 times
2. As we talked about in class, electron-deficient aromatic halides undergo nucleophilic aromatic substitution (NAS) reactions in the presence of strong nucleophiles like hydroxide anion. Somewhat surprisingly, this NAS reaction occurs faster when fluorine is substituted for than when chlorine is substituted for OH Өон e х X=F is faster than X = CI NOZ NO2 Explain why this is so. Show the mechanism of the reaction. Consider which step of the mechanism is the slow (rate-determining) step of the mechanism and how that can be used to explain the trend with the halogen groups noted above. (5 pts).