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The graph below shows concentration-response curves for an agonist (Drug X) in the absence and presence of an antagonist (Drug Y). 100 • Drug X O Drug X + Drug Y 80- 60 Response (% maximum) 40- 20- -9 -6 -5 -8 -7 [Drug X] log M
c) Drug Z is an antagonist that binds covalently to the target receptor of Drug X. Describe what you might expect to observe when generating a log concentration-response curve to Drug X in the presence of Drug Z. (3 marks) d) Based on the concentration-response curve for Drug X, discuss how a partial agonist targeting the same receptor (as Drug X) can antagonise the response of Drug X. In your answer, you should also comment on how the partial agonist would alter the concentration-response curve for Drug X. (3 marks)